27.膳食核苷酸通过减轻炎症和调节大鼠肠道微生物群来预防酒精性肝损伤1.World Health Organization, Global statusreport on alcohol and health 2014. Available from: URL:http://apps.who.int/iris/bitstream/10665/112736/1/9789240692763_eng.pdf?ua=1. 2.L. A. Streba, C. C. Vere, C. T. Strebaand M. E. Ciurea, Focus on alcoholic liver disease: From nosography totreatment,World J. Gastroenterol., 2014, 20(25), 8040–8047. 3.S. Fleming, S. Toratani, T.Shea-Donohue, Y. Kashiwabara, S. N. Vogel and E. S. Metcalf, Pro- andAnti-Inflammatory Gene Expression in the Murine SmallIntestine and Liver after Chronic Exposure to Alcohol,Alcohol.: Clin. Exp. Res.,2001, 25(4), 579–589. 4.B. Lin, F. Zhang, Y. Yu, Q. Jiang, Z.Zhang, J. Wang and Y. Li, Marine collagen peptides protectagainst early alcoholic liver injury in rats, Br. J. Nutr., 2012, 107(8),1160–1166. 5.G. Szabo, P. Mandrekar, J. Petrasek andD. Catalano, The unfolding web of innate immunedysregulation in alcoholic liver injury, Alcohol.: Clin. Exp. Res.,2011, 35(5), 782–786. 6.A. Rocco, D. Compare, D. Angrisani, M.Sanduzzi Zamparelli and G. Nardone, Alcoholicdisease: Liver and beyond, World J. Gastroenterol., 2014,20(40), 14652–14659. 7.P. D. Cani and N. M. Delzenne, Gutmicroflora as a target for energy and metabolic homeostasis,Curr. Opin. Clin. Nutr. Metab. Care., 2007, 10(6), 729–734. 8.S. R. Gill, M. Pop, R. T. Deboy, P. B.Eckburg, P. J. Turnbaugh, B. S. Samuel, J. I.Gordon, D. A. Relman, C. M. Fraser-Liggett and K. E. Nelson,Metagenomic analy sis of the human distal gut microbiome,Science, 2006, 312(5778), 1355–1359. 9.P. J. Turnbaugh, R. E. Ley, M. Hamady,C. M. Fraser Liggett, R. Knight and J. I. Gordon, Thehuman micro biome project, Nature, 2007, 449(7164),804–810. 10.F. Casafont Morencos, G. de las HerasCastaño, L. Martín Ramos, M. J. Arias, F. Ledesma and F. PonsRomero, Small bowel bacterial overgrowth in patientswith alcoholic cirrhosis, Dig. Dis. Sci., 1996, 41(3),552–556. 11.A. Keshavarzian, A. Farhadi, C. B.Forsyth, J. Rangan, S. Jakate, M. Shaikh, A. Banan and J. Z.Fields, Evidence that chronic alcohol exposure promotesintestinal oxidative stress,intestinal hyperpermeability and endotoxemia priorto development of alcoholic steatohepatitis in rats, J. Hepatol., 2009, 50(3),538–547. 12.H. J. Wang, B. Gao, S. Zakhari and L.E. Nagy, Inflam mation in Alcoholic Liver Disease, Annu.Rev. Nutr., 2012, 32, 343–368. 13.A. W. Yan, D. E. Fouts, J. Brandl, P.Stärkel, M. Torralba, E. Schott, H. Tsukamoto, K. E. Nelson, D. A. Brenner andB. Schnabl, Enteric dysbiosis associated with a mouse model of alcoholic liverdisease, Hepatology, 2011, 53(1), 96–105. 14.P. Mandrekar and G. Szabo, Signallingpathways in alcoholinduced liver inflammation, J. Hepatol., 2009, 50(6),1258–1266. 15.A. Parlesak, C. Schäfer, T. Schütz, J.C. Bode and C. Bode, Increased intestinal permeability to macromolecules andendotoxemia in patients with chronic alcohol abuse in difffferent stages of alcohol-inducedliver disease, J. Hepatol., 2000, 32(5), 742–747. 16.M. Fujimoto, M. Uemura, Y. Nakatani, S.Tsujita, K. Hoppo, T. Tamagawa, H. Kitano, M.Kikukawa, T. Ann, Y. Ishii, H. Kojima, S. Sakurai, R.Tanaka, T. Namisaki, R. Noguchi, T. Higashino, E. Kikuchi, K.Nishimura, A. Takaya and H. Fukui, Plasma endotoxinand serum cyto kine levels in patients with alcoholichepatitis: relation to severity of Liver disturbance, Alcohol.: Clin. Exp.Res., 2000,24(4 Suppl), 48S–54S. 17.A. A. Nanji, K. Jokelainen, A.Rahemtulla, L. Miao, F. Fogt,H. Matsumoto, S. R. Tahan and G. L. Su, Activationof nuclear factor kappa B and cytokineimbalance in experi mental alcoholic liver disease in the rat,Hepatology, 1999, 30(4), 934–943. 18.M. G. Neuman, Y. Maor, R. M. Nanau, E.Melzer, H. Mell, M. Opris, L. Cohen and S. Malnick,Alcoholic Liver Disease: Role of Cytokines, Biomolecules, 2015,5(3), 2023–2034. 19 M. M. Jaurigue and M. S. Cappell,Therapy for alcoholic liver disease, World J. Gastroenterol.,2014, 20(9), 2143–2158. 20.M. I. Torres, M. I. Fernández, A. Giland A. Ríos, Dietary nucleotides have cytoprotective properties in rat liverdamaged by thioacetamide, Life Sci., 1998, 62(1), 13–22. 21.S. Iijima, T. Tsujinaka, M. Kishibuchi,Y. Kido, C. Ebisui, K. Kan, M. Yano and T. Mori, A total parenteral nutrition solution supplemented with a nucleosideand nucleotide mixture sustains intestinal integrity, butdoes not stimulate intestinal function after massive bowel resection inrats,Nutr, 1996, 126(3), 589–595. 22 M. E. Evans, J. Tian, L. H. Gu, D. P.Jones and T. R. Ziegler, Dietary Supplementation With Orotate and UracilIncreases Adaptive Growth of Jejunal Mucosa After Massive Small Bowel Resectionin Rats, JPEN, J. Parenter. Enteral Nutr., 2005, 29(5), 315–321. 23.A. Gil, Modulation of the immuneresponse mediated by dietary nucleotides, Eur. J. Clin. Nutr.,2002, 56(Suppl. 3), S1–S4. 24.A. Singhal, G. Macfarlane, S.Macfarlane, J. Lanigan, K. Kennedy, A. Elias-Jones, T. Stephenson,P. Dudek and A. Lucas, Dietary nucleotides and fecalmicrobiota in formula-fed infants: a randomizedcontrolled trial, Am. J. Clin. Nutr., 2008, 87(6),1785–1792. 25.C. Quast, E. Pruesse, P. Yilmaz, J.Gerken, T. Schweer, P. Yarza, J. Peplies and F. O. Glöckner,The SILVA ribosomal RNA gene database project: improved dataprocessing and web-based tools, Nucleic Acids Res., 2013,41(Database issue), D590–D596. 26.Q. Wang, G. M. Garrity, J. M. Tiedjeand J. R. Cole, Naive Bayesian classifier for rapid assignmentof rRNA sequences into the new bacterial taxonomy, Appl.Environ. Microbiol., 2007, 73(16), 5261–5267. 27.M. A. Ortega, M. C. Nunez, A. Gil andA. Sánchez-Pozo, Dietary nucleotides accelerate intestinalrecovery after food deprivation in old rats, J. Nutr., 1995,125(6), 1413–1418. 28.C. P. Dancey, E. A. Attree and K. F.Brown, Nucleotide supplementation: a randomised double-blind placebo controlledtrial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449],Nutr. J., 2006, 5, 16. 29.Y. Wang, I. Kirpich, Y. Liu, Z. Ma, S.Barve, C. J. McClain and W. Feng, Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-induciblefactor, promotes intestinal integrity and amelioratesalcohol-induced liver injury, Am. J. Pathol., 2011, 179(6), 2866–2875. 30.B. Koletzko, S. Baker, G. Cleghorn, U.F. Neto, S. Gopalan,O. Hernell, Q. S. Hock, P. Jirapinyo, B. Lonnerdal, P. Pencharz, H. Pzyrembel, J.Ramirez-Mayans, R. Shamir, D. Turck, Y. Yamashiro and D. Zong-Yi,Global standard for the composition of infant formula:recommendations of an ESPGHAN coordinated internationalexpert group, J. Pediatr. Gastroenterol. Nutr., 2005,41(5), 584–599. 31.M. Xu, Y. Ma, L. Xu, Y. Xu and Y. Li,Developmental effffects of dietary nucleotides in second-generation weanedrats, J. Med. Food, 2013, 16(12), 1146–1152. 32.B. Gao and R. Bataller, Alcoholic liverdisease: pathogenesis and new therapeutic targets, Gastroenterology, 2011,141(5), 1572–1585. 33.J. Liu, Ethanol and liver: recentinsights into the mechanisms of ethanol-induced fatty liver, World J.Gastroenterol., 2014, 20(40), 14672–14685. 34.N. Horiguchi, L. Wang, P. Mukhopadhyay,O. Park, W. I. Jeong, F. Lafdil, D. Osei-Hyiaman, A. Moh, X. Y. Fu, P. Pacher, G. Kunos and B. Gao, Cell type-dependentpro and anti-inflammatory role of signaltransducer and activator of transcription 3 in alcoholic liver injury,Gastroenterology, 2008, 134(4), 1148–1158. 35.F. Hong, W. H. Kim, Z. Tian, B. Jaruga,E. Ishac, X. Shen and B. Gao, Elevated interleukin-6 duringethanol con sumption acts as a potential endogenousprotective cyto kine against ethanol-induced apoptosis inthe liver: involvement of induction of Bcl-2 andBcl-x(L) proteins, Oncogene, 2002, 21(1), 32–43. 36.L. Bavia, Í. A. de Castro and L. Isaac,C57BL/6 and A/J Mice Have Difffferent Inflammatory Response and Liver LipidProfile in Experimental Alcoholic Liver Disease, Mediators Inflammation, 2015,2015, 491641. 37.F. M. Chang, S. M. Reyna, J. C.Granados, S. J. Wei, W. Innis-Whitehouse, S. K. Maffiffiffi, E.Rodriguez, T. J. Slaga and J. D. Short, Inhibition of neddylation represseslipopolysaccharide-induced proinflammatory cytokine production in macrophagecells, J. Biol. Chem., 2012, 287(42), 35756– 35767. 38.V. Purohit, J. C. Bode, C. Bode, D. A.Brenner, M. A. Choudhry, F. Hamilton, Y. J. Kang,A. Keshavarzian, R. Rao, R. B. Sartor, C. Swanson and J. R.Turner, Alcohol, intestinal bacterial growth, intestinalpermeability to endotoxin, and medical consequences:summary of a symposium, Alcohol, 2008, 42(5), 349–361. 39.D. Compare, P. Coccoli, A. Rocco and O.M. Nardone, Maria .S. De, M. Cartenì, G. Nardone,Gut–liver axis: the impact of gut microbiota on non alcoholicfatty liver disease, Nutr., Metab. Cardiovasc. Dis,2012, 22(6), 471–476. 40.I. A. Kirpich, N. V. Solovieva, S. N.Leikhter, N. A. Shidakova, O.V.Lebedeva,P. I. Sidorov, T. A. Bazhukova, A. G.Soloviev,S. S. Barve, C. J. McClain and M. Cave, Probiotics restore bowel floraand improve liver enzymes in human alcoholinduced liver injury: a pilot study,Alcohol, 2008, 42(8), 675–682. 41.S. Leclercq, S. Matamoros, P. D. Cani,A. M. Neyrinck, F. Jamar, P. Stärkel, K. Windey, V.Tremaroli, F. Bäckhed, K. Verbeke, P. de Timary and N. M.Delzenne, Intestinal permeability, gut-bacterial dysbiosis, andbehavioral markers of alcohol-dependence severity,Proc. Natl. Acad. Sci. U. S. A., 2014, 111(42), E4485–E4493. 42.A. W. Yan, D. E. Fouts, J. Brandl, P.Stärkel, M. Torralba,E. Schott, H. Tsukamoto, K. E. Nelson, D. A. Brenner andB. Schnabl, Enteric dysbiosis associated with a mouse model of alcoholic liverdisease, Hepatology, 2011, 53(1),96–105. 43.S. Ceccarelli, V. Nobili and A. Alisi,Toll-like receptor mediated signaling cascade as a regulator of the inflammationnetwork during alcoholic liver disease, World J. Gastroenterol., 2014, 20(44),16443–16451. 44.C. Schäfer, A. Parlesak, C. Schütt, J.C. Bode and C. Bode,Concentrations of lipopolysaccharide- bindingprotein,bactericidal/permeability-increasing protein, soluble CD14 and plasmalipids in relation to endotoxaemia in patients with alcoholic liver disease,Alcohol, 2002, 37(1), 81–86. 45.I. Hritz, P. Mandrekar, A. Velayudham,D. Catalano, A. Dolganiuc, K. Kodys, E. Kurt-Jones andG. Szabo, The critical role of toll-like receptor (TLR)4 in alcoholic liver disease is independent of the common TLR adapter MyD88, Hepatology, 2008, 48(4), 1224–1231. 46.C. A. Bradham, J. Plümpe, M. P. Manns,D. A. Brenner and C.Trautwein, Mechanisms of hepatictoxicity. I. TNF induced liver injury, Am. J. Physiol.,1998, 275(3 Pt 1), G387–G392. 47.C. J. Lin, C. C. Chiu, Y. C. Chen, M.L. Chen, T. C. Hsu and B. S. Tzang, Taurine Attenuates Hepatic Inflammation in Chronic Alcohol-Fed Rats ThroughInhibition of TLR4/MyD88 Signaling, J. Med. Food, 2015,18(12), 1291– 1298. 48.J. Khoury, J. C. Ibla, A. S. Neish andS. P. Colgan, Antiinflammatory adaptation to hypoxia through adenosinemediatedcullin-1 deneddylation, J. Clin. Invest., 2007, 117(3), 703–711. Paper Food& Function 2908 | Food Funct., 2016, 7, 2898–2908 This journal is © The Royal Society of Chemistry 2016 ViewArticle Online Published on 24 May 2016. Downloaded byFLORIDA ATLANTIC UNIVERSITY |