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23.膳食核苷酸延长SPRAGUE-DAWLEY大鼠的寿命

1.Everitt AV, Hilmer SN, Brand-Miller IC,Jamieson HA, Truswell AS, Sharna AP, MasonRS, Morris BJ, Le Couteur DG (2006)Dietary approaches that delay age-related diseasesClin Interv Aging 1:11-313

2.Zhao X,Zhang L (2000) Effects of nucleicacies on aging. Chin J Geriatr 19:72-73

3.Sanchez-Pozo A, Gil A (2002) Nucleotidesas semiessential nutritional components. Br jNutr 87 Suppl 1:S135-S137

4.Frankic T Pajk T Rezar V, Levart A,Salobir J (2006) The role of dietary nucleotides inreduction of DNA damageinduced by T-2 toxin and deoxynivalenol in chickenleukocytes,Food Chem Toxicol44:1838-1844

5.Tahmasebi-Kohyani A, Keyvanshokooh S,Nematollahi A, Mahmoudi N, Pasha-ZanoosiH (2011) Dietary administration ofnucleotides to enhance growth, humoral immuneresponses, and disease resistanceof the rainbow trout (Oncorhynchus ykiss) fingerlingsFish Shellfish Immunol30:189-1937.

6.Yokoyama H, Fujiwara H, Watanabe H(2004) Dietary nucleosides and nucleotides do notaffect tumor incidence butreduce amyloidosis incidence in B6C3F1 mice inadiatedwithcalifomnium-252.Nutrition 20:383-389

7..Fontana L, Moreira E, Torres Ml,Fernandez I, Rios A, Sanchez DMF, Gil A (1998)Dietary nucleotides correctplasma and liver icrosomal fatty acid alterations in rats withliver cinhosisinduced by oral intake of thioacetamide,J Hepatol 28:662-669

8.Jyonouchi H, Sun SWinship T, Kuchan M](2003) Detary ribonucleotides increascantigen-specific type 1 T-helper cells inthe regional draining lymph nodes in youngBALB/cJ miceNutrition 19:41-46

9.Lopez-Navarro ATOrtega MA, Peragon JBueno JD, Gi A Sanchez-Poz0 A (1996Deprivation of dietary nucleotides decreasesprotein synthesis in the liver and smalintestine in rats,Gastroenterology110:1760-1769

10.Iwasa Y,Iwasa M, Ohmori Y, Fukutomi T,Ogoshi S (2000) The effect of theadministration of nucleosides and nucleotidesfor parenteral use. Nutrition 16:598-602

11.Sauer N, Bauer E, Vahjen W,Zentek J,Mosenthin R (2010) Nucleotides modify growth ofselected intestinaf bacteria invito, Livestock Science l33:161-163

12.Chcn TH, Wang MF,Liang YF,KomatsuT,Chan YC,Chung SY,Yamamoto S (2000) Anucleoside-nucleotidc mmixture may reducememory deterioration in old senescenceaccelerated mice.JNutr 130:3085-3089

13.Chen TH,Huang HPMatsumoto Y,Wu SH, WangMF,Chung SY, Uezu K, MoriyamnT, Uezu E, Korin T, Sato S, Yarnarnoto S (1996)Effects of dietary nucleoside-nucleotidemixture on memory in aged and youngmemory deficient mice, Life Sci 59:1325-1 330

14.Anisimov VN (2001) Life span extensionand cancer risk: yths and reality, Exp Gerontol36:1101-1136

15.National Institutes of Health: Guidefor theCare and Usc of Laboratory AnimalsNIHPublication number 85-23 NationalInstitutes of Health Bethesda MD1985

16.Cavigelli SA, Bennett JM, Michael KCKlein LC (2008) Female temperament, tumoldevelopment and life span: relation toglucocorticoid and tumor necrosis factor alpha levelin rats.Brain Behay Immun22:727-735

17.Lautermann J, Crann SA McLaren J,Schacht J (1997) Glutathione-dependent antioxidantsysteins in the mammalianinner ear; effects of aging, ototoxic drugs and noise. Hear Ref114:75-82

18.Bermabucci U,Ronchi B,LaceteraN,Nardone A (2005) Influence of body condition scoreon relationships beteenetabolic status and oxidative stress in periparturient dairy cowsJDairy Sci88:2017-2026

19.Guichardant M,Chantegrel B, Deshayes C,Doutheau A, Moliere P, Lagarde M (2004)Specific markers of lipid peroxidationissue from n-3 and n-6 fatty acids, Biochem SocTrns 32:139-140

20.Mesia-Vela S, Sanche2 RI, Roberts KG,Reuhl KR, Conney AH, Kanffman FC: Dielaryclofbrate stimulates the fonmation andsize of estradiol-induced brcast tumors in femaleAugust-Copenhagen Irish(ACDrats.Toxicology 2008;246:63-67

21.Gart J, Krewski D, Lee PN, Tarone RE, WahrendorfJ: IARC Scientific PublicationsNumber 79: Statistical Methods in CancerResearch, Vol. I-The Design and Analysis ofL_ong-Term Animal Experiments.International Agency for Research on Cancer, Lyon.France.1986.

22.Peto R, Pike MC, Day NE, et al.: Guidelinesfor simple, sensitive significance tests forcarcinogenic effects in long-termanimal experiments, TARC Monogr Eval Carcinog RiskChem Hum Suppl 1980:(2Suppi):311-426

23.Nakazawa M,Tawaratani T,Uchimolo H,Kawaminami A, Ueda M, Ueda A, Shinoda YIwakura K, Kura K Sumi N (2001)Spontaneous neoplastic lesions in aged SpragucDawley rats Exp Anim 50:99-103

24.Vogelstein B, Kinzler KW (2004) Cancergenes and the pathways they control, Nat Med10:789-799

25.CammpisiJ(2000) Cancer,aging andcelfular senescence.In Vivo 14:183-188

26.Baldrick P(2005 Carcinogenicitvevaluation: comparison of tumor data from dunl controgroups in theSprague-Dawley rat.Toxicol Pathol 33:283-291
27.Dirx MJ, Zeegers MP, Dagnelie PC, van den Bogaard T, van den Brandt PA (2003Energyrestriction and the risk of spontancous mammary tumors in mice: ameta-analysis.IntJCancer 106:766-770

28.Lopez-Torres M, Gredilla R, Sanz A,Bauja G (2002) Influence of aging and long-tenncaloric restriction on oxygenradical generation and oxidative DNA damage in rat livermitochondriaFree RadicBiol Med 32:882-88929

29.Sohal RS, Weindruch R (1996) Oxidativestress, caloric restriction, and aging. Science273:59-63

30.Rcbrin 1, Kamzalov S,Soha] RS (2003)Effects of age and caloric restriction onglutathione redox state in mice,FreeRadic Biol Med 35:626-635

31.Sun Y (1990) Free radicals, antioxidantenzymes, and carcinogenesis. Free Radic Biol31Med 8:583-599

32.Barja G (2004) Free radicals andaging.Trends Neurosci 27:595-600)

33.Kim JW,No JK, Ikeno Y, Yu BP, Choi JS,Yokozawa T, Chung HY (2002) Age-relatedchanges in redox status of rat serum.Arch Gerontol Geriatr 34:9-17

34.Inal ME, Kanbak G, Sunai E (2001)Antioxidant enzyme activities and malondialdehydelevels related to aging.CinChim Acta 305:75-80

35.Niedernhofer LJ,Daniels JS,Rouzer CA,Greene RE,Marnett LJ(2003)Malondialdehyde, a product of lipid peroxidation, is mutagenic in humancells, J Biol Chem 278:31426-31433

36.Ames BN,Shigenagu MK,Hagen TM (1993)Oxidants,antioxidants, and the degenerativcdiseases of aging.Proc Natl AcadSciU S A 90:7915-7922

37.Van Remmen H, Ikeno Y, Hamilton M,Pahlavani M, Wolf N, Thorpe SR, Alderson NLBaynes JW, Epstein CJ, Huang TT,Nelson J, Strong R, Richardson A (2003) Life-longreduction in MnSOD activity resultsin increased DNA damage and higher incidence ofcancer but coes not acceferateaging. Physiol Genomics 16:29-37